Humic substances play a key role in recycling of nutrients (MacCarthy, 2003). Humates are used in soil or sprayed on plants (foliar application) mainly because of their very high content of humic acids, ranging from 30 to 60% and can be taken up easily by the roots (Stevenson and Cole, 1999). Combining organic and mineral inputs has been realized as most economical for maize and soybean crops (Vanlauwe and Zingore, 2011). Therefore, the present study was planned to evaluate the efficacy of potassium humate (K. humate) applications to improve yield attributes and determine its synergistic effect with NPK on potato production. Further, to assess the most effective and economical combination of NPK and potassium humate for its better performance under agroclimatic conditions of Multan (Pakistan).